Description
Product Characteristics: Synonyms:
Fug 1 antibody,Fug1 antibody,KIAA1835 antibody,MGC20266 antibody,OTTHUMP00000028918antibody,RAGP1_HUMAN antibody,Ran 1 antibody,RAN GTPase activating protein 1 antibody,Ran GTPase-activatingprotein 1 antibody,Ran1 antibody,RANGAP 1 antibody,RanGAP1 antibody,SD antibody,Segregation distorterhomolog antibody,Segregation distortion antibody
Target Information: RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq, Jul 2008]